The 21st Century BrainTrust® (21CBT) is a virtual research platform that promotes brain health through innovation. Think new digital biomarkers, mapped using the power of self-administered cognitive testing as a sensitive, early screening tool for all brain traumas, Alzheimer’s and related dementias. 21CBT promotes novel technologies that offer low-cost screening capabilities for future prevention trials to facilitate enrollment, as well as exploratory trial endpoints. 21CBT is a collaboration of the Geoffrey Beene Foundation Alzheimer’s Initiative, BrightFocus Foundation, Cleveland Clinic/Lou Ruvo Brain Institute and UsAgainstAlzheimer’s.